Session I-12: Epigenetics and its increasing relevance in toxicology and risk assessment Session I -12: Oral presentations
نویسندگان
چکیده
the term “epigenetics” was coined in the 1940s and denotes the heritable changes in the phenotype or gene expression patterns caused by mechanisms other than changes in the underlying DNA sequence. Since its introduction, the epigenetics research field has experienced a true boost, particularly in the last two decades, with the in-depth characterization of the determinants of the epigenome and the establishment of cutting-edge technology to study these features as milestones. the major drivers of the epigenetic machinery, including DNA methylation, histone modifications and regulation by non-coding RNA species, will be briefly discussed in the current presentation. Furthermore, the increasing relevance of epigenetics for both the study and practice of toxicology will be illustrated. I-12-718 An introduction to epigenetics
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